【文献标题】A Nasal Temperature and pH Dual-Responsive In Situ Gel Delivery System Based on Microemulsion of Huperzine A:ormulation, Evaluation, and In Vivo Pharmacokinetic Study

【作者】Yifan Chen，Gang Cheng，Rongfeng Hu，et.al

【作者单位】安徽中医药大学（Anhui University of Chinese Medicine）

【文献中引用产品】

试剂-氨基甲酸乙酯

【关键词】huperzine A; microemulsion; nasal administration; dual-responsive in situ gel;microdialysis.

【DOI】DOI: 10.1208/s12249-019-1513-x

【影响因子(IF)】4.0

【出版期刊】《AAPS PharmSciTech 》

【产品原文引用】

Huperzine A (purity > 99%) was obtained from Wanbang Pharmaceutical Co., Ltd. (Zhejiang, China).Pluronic F127 and F68 were obtained from BASF (Germany). Chitosan (Mw 7.8 × 105; degree of deacetylation was 80.0~95.0%) was purchased from Sinopharm Chemical Reagent Co., Ltd. (Shanghai, China, medicinal grade).Castor oil was purchased from Sinopharm Group Chemical Reagent Co., Ltd. (Shanghai, China). Polyoxyl 40 hydrogenated castor oil (Cremophor RH40) and 1,2-propanediol were obtained from BASF (Germany) and Tianjin Damao Chemical Reagent Factory (Tianjin, China),respectively. Acetonitrile and methanol (HPLC grade) were obtained from Sigma-Aldrich Co., Ltd. (Shanghai, China).Ringer’s solution was purchased from Anhui Provincial Hospital of Traditional Chinese Medicine (Hefei, China).Urethane was obtained from Shanghai Hengyuan Technology Co., Ltd. (Shanghai, China). All other reagents used in this study were of analytical grade.

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